Clermont lost to Munster back in Round 2 in December, they have not lost back-to-back matches in the Champions Cup since January 2016.
At home, Wasps have lost just one of their last 14 home games against TOP 14 opposition (W12, D1).
Wasps were one of five sides to claim a maximum 10 match points from their two pool stage
matches in the Champions Cup this season, beating both Montpellier and Dragons with try-scoring bonus points.
Wasps and Clermont have met just twice before in the Champions Cup, a pair of pool stage matches in 2007/08 which were both won by the home side on the day.
This weekend marks the first time in the history of tournament that a Round of 16 will be played as part of the knockout stage.
Six tournament winners - Exeter Chiefs, Leinster Rugby, Munster Rugby, RC Toulon, Toulouse and Wasps - with 16 Heineken Champions Cup titles between them have qualified for the knockout stage.