One change in the back row, as Steven Luatua fails late fitness test. Fitz Harding moves across to number 8 with Chris Vui shifting to blindside and Ed Holmes in the second row. Jake Heenan captains the side.
Defending champions Harlequins host the Bristol Bears in round 4 of the Premiership. Harlequins have won both of their opening two matches to sit third in the table, while the Bristol Bears have recorded a single victory from their three games to lie second from bottom of the standings.
Chris Vui switches back into the second row with Harding lining up alongside Jake Heenan and skipper Steven Luatua in the back row.
Fitz Harding is set for his first outing of the season for Bristol Bears when they travel to the Premiership champions on Friday evening
Fly-half Smith is the sole change to the match day 23 for the Club this week, replacing Scottish international Huw Jones on the bench as Quins opt for consistency for what is set to be a thrilling encounter on Friday evening.