Exeter have won 100% of their rucks in the Champions Cup this season (82/82), no other side has a perfect rate in this facet of the game.
Lyon are the only side to win all of their lineouts (11/11) and scrums (4/4) in the Champions Cup so far this season.
Exeter beat Glasgow 42-0 in Round 1 earlier this season, their biggest ever win in the Champions Cup
Lyon are playing their first ever knock-out match in European competition, they will be looking for a first Champions Cup victory away from home (L6, exc. Round 2 fixture v Glasgow).
Exeter have won their last five completed fixtures against French opponents in the Champions Cup, as many as they had recorded in all of their previous 15 such matches.
Reigning Champions Cup champions, Exeter, have won their last seven home games in a row in the tournament, one more win would set a club record for consecutive home wins in Europe (across both the Champions Cup and Challenge Cup)
This will be the first meeting between Exeter and Lyon in European competition.
This weekend marks the first time in the history of tournament that a Round of 16 will be played as part of the knockout stage.
Six tournament winners - Exeter Chiefs, Leinster Rugby, Munster Rugby, RC Toulon, Toulouse and Wasps - with 16 Heineken Champions Cup titles between them have qualified for the knockout stage.