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Exeter have won 100% of their rucks in the Champions Cup this season (82/82), no other side has a perfect rate in this facet of the game.
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Lyon are the only side to win all of their lineouts (11/11) and scrums (4/4) in the Champions Cup so far this season.
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Exeter beat Glasgow 42-0 in Round 1 earlier this season, their biggest ever win in the Champions Cup
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Lyon are playing their first ever knock-out match in European competition, they will be looking for a first Champions Cup victory away from home (L6, exc. Round 2 fixture v Glasgow).
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Exeter have won their last five completed fixtures against French opponents in the Champions Cup, as many as they had recorded in all of their previous 15 such matches.
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Reigning Champions Cup champions, Exeter, have won their last seven home games in a row in the tournament, one more win would set a club record for consecutive home wins in Europe (across both the Champions Cup and Challenge Cup)
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This will be the first meeting between Exeter and Lyon in European competition.
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This weekend marks the first time in the history of tournament that a Round of 16 will be played as part of the knockout stage.
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Six tournament winners - Exeter Chiefs, Leinster Rugby, Munster Rugby, RC Toulon, Toulouse and Wasps - with 16 Heineken Champions Cup titles between them have qualified for the knockout stage.