The proven Six Nations pedigree Wales are missing
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Wales kick off their Six Nations defence without the services of proven class with the likes of George North, Taulupe Faletau, Leigh Halfpenny, Josh Navidi, Ken Owens and Justin Tipuric also sidelined.
Head coach Wayne Pivac said his squad has lost around 680 caps' worth of experience, but Wales should still be no mugs.
The players Pivac has chosen for the tournament come with an average of 27.1 Test caps of experience, only topped by Ireland's 30.9 among the six teams.
Those that are missing are proven class, however. In last year's championship, Faletau had 66 carries, putting him in third place among all players, while Tipuric made the most tackles (82). Faletau was fourth on that list (74), and skipper Jones was sixth (72).
On the Six Nations all-time list, North, who has featured on the wing and at outside centre, ranks fourth for metres gained (2,548), third for defenders beaten (126), and third for most clean breaks (48).
Jones is top of the all-time tackles chart (719).
To lose a raft of proven top-level talent would hurt any team, and George North is not blind to that. He has been in and around the Wales squad since his late teens, however, so is certain there will be no defeatist attitude in Pivac's camp.
Speaking to Stats Perform News, Goerge North said:
"Obviously there are a number of players out missing, and I think Wayne's come out with a stat of something like 680 caps that he's lost."
"That's a tough place to be."
But can Wales kick on regardless? North says so.
"Well, that that's the only way you get better, isn't it? By pushing the standards up every time," North tells Stats Perform News.
"I think for us, as Wales, we're used to being the underdogs, and we're always used to being kind of like always wanting more, and I think that shows in the performances that we have and the results we have had of late.
"From the lads' point of view, that's something they will certainly be looking at: how they push on from last year. Obviously winning the championship [is one thing], but you know the next step is backing it up again and as we said, it's going to be incredibly tough for the boys."