Fresh from a famous Calcutta Cup triumph, Scotland will look to make it two wins out of two when they do battle with Wales.
Buoyant Scotland will go in search of back-to-back wins over Wales for the first time in 18 years and France travel to Ireland for a mouthwatering Six Nations showdown this weekend.
Scotland ended a 38-year wait for a win at Twickenham on the opening weekend with a dominant 11-6 defeat of the defending champions.
Gregor Townsend's side need to follow that up on Saturday with a victory over a Wales side that got the better of 14-man Ireland at the Principality Stadium following Peter O'Mahony's first-half red card.
France started the tournament by hammering Italy 50-10, but will face a bigger test in Dublin, while England should respond to their Calcutta Cup defeat by beating Italy at home on Saturday.
Ahead of the second round, we preview the upcoming matches with help from Opta.
ENGLAND v ITALY
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The Red Rose have won each of their 21 fixtures against Italy in the Six Nations, and they are the only team yet to suffer defeat against the Azzurri in the championship.
England have hosted Italy on 10 occasions in the Six Nations, winning each of those 10 fixtures by an average margin of 31 points and scoring 5.6 tries per game.
Italy have won just twice away from home in the Six Nations (losing 50 and drawing one), with both victories coming against Scotland at Murrayfield (2007 and 2015).
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ONES TO WATCH
George Ford comes into the England side, with captain Owen Farrell moving to outside centre, in one of five changes to the side, and the fly-half will be ready to make a statement after being named on the bench for the loss to Scotland.
Italy endured a torrid start to the competition, but Luca Sperandio scored a fine try. The wing had seven carries and made 52 metres. The Azzurri will need to get Sperandio flying down the flank again in London.
SCOTLAND v WALES
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Scotland were superb against England and will be aiming for consecutive wins over Wales in the Six Nations for the first time since 2002-2003.
Wales had an extra man, but Ireland could consider themselves unfortunate to go down 21-16 in Cardiff. The Welsh have lost their last six Tests away from home and will be in for another huge battle at Murrayfield.
They have conceded 30 points per game in that miserable sequence of matches on their travels.
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ONES TO WATCH
Captain Stuart Hogg was man of the match in a rousing performance from Scotland against Eddie Jones' men. The full-back made 112 metres and had 13 carries. He was also brilliant with the boot, kicking for 367 metres.
Louis Rees-Zammit showed why he is so highly rated in Wales' win over Ireland. He dived to finish magnificently in the corner as Wayne Pivac's side made a winning start at home last Sunday.
IRELAND v FRANCE
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Flanker O'Mahony's reckless dismissal proved to be costly for Andy Farrell's Ireland side in Cardiff. They will be looking to avoid suffer back-to-back losses to Les Bleus in the Six Nations, having not endured such a fate since 2010-11.
Ireland have won five of their last seven clashes with France in the Six Nations (L2) after winning only four of their 30 previous meetings with them in the Five/Six Nations (D3 L23).
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ONES TO WATCH
Antoine Dupont was the player of the opening round of the tournament. The mercurial scrum-half assisted four tries, the joint-most by any player in a Six Nations match, equalling the record set by Frederic Michalak against Italy in 2006. He also scored a try of his own in a sublime performance.
Ireland lock Tadhg Beirne made the most carries (21) of any player in the opening round. He also hit the most rucks of any player (48) and was Ireland’s joint-highest tackler (10, level with CJ Stander).
