Scotland can expect an Ireland backlash at Murrayfield, while England and Wales head into round two on a high after making winning starts.
Scotland will be out to claim a record-equalling eighth consecutive home victory in the Six Nations when they face a wounded Ireland, while England and Wales are strong favourites to make it two wins out of two.
Ireland were rocked by England in Dublin last Saturday, the defending champions and 2018 Grand Slam winners going down 32-20 at the Aviva Stadium.
Scotland started the tournament with a 33-20 victory over Italy at Murrayfield and will be looking to show they are genuine title contenders by inflicting more misery on the injury-hit holders on Saturday.
In the final match of the weekend on Sunday, England will be expected to see off a France side smarting from a second-half collapse against Wales in the opening game of the tournament in Paris last Friday.
Warren Gatland has made 10 changes to his side to face Italy, but Wales should still have too much for the Azzurri in Rome on Saturday.
With the help of Opta, we take a statistical look at the second round of matches.
Scotland v Ireland
Scotland have not reeled off eight victories in a row in the tournament since achieving the feat between 1972 and 1975.
Gregor Townsend's men can expect a backlash from an Ireland side attempting to avoid back-to-back defeats for the first time since their tour of South Africa in 2016.
Ireland have won four of their last five Six Nations matches against Scotland, the one defeat coming at Murrayfield two years ago.
Captain Greig Laidlaw needs 10 points to overtake Gavin Hastings's tally of 667 and become Scotland's second-highest points scorer behind Chris Paterson (809).