Arthur Vincent and Jayden Hayward come into the France and Italy starting line-ups respectively for the match in Paris.
France and Italy both make just one change to their starting line-ups for the Six Nations clash at the Stade de France on Sunday.
Former Les Bleus Under-20 captain Arthur Vincent replaces powerhouse centre Virimi Vakatawa, who suffered a triceps injury in the victory over England last Sunday, to make his first Test start.
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Romain Taofifenua replaces Vincent in the matchday squad, so Fabien Galthie has six forwards to call upon among the replacements in Paris.
Italy were thumped 42-0 by Wales in their opener, but Jayden Hayward's inclusion at full-back is the only alteration made by Franco Smith.
Matteo Minozzi shifts from number 15 to the left wing, with Leonardo Sarto overlooked for the Azzurri's second match of the tournament.
France have triumphed in 18 of their 20 clashes with Italy in the Six Nations, including winning all 10 of their home games.
WATCH: Omar Mouneimne analyses England & France:
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France: Anthony Bouthier, Teddy Thomas, Arthur Vincent, Gael Fickou, Vincent Rattez, Romain Ntamack, Antoine Dupont; Cyril Baille, Julien Marchand, Mohamed Haouas, Bernard Le Roux, Paul Willemse, Francois Cros, Charles Ollivon (captain), Gregory Alldritt.
Replacements: Peato Mauvaka, Jefferson Poirot, Demba Bamba, Romain Taofifenua, Boris Palu, Cameron Woki, Baptiste Serin, Matthieu Jalibert.
Italy: Jayden Hayward, Mattia Bellini, Luca Morisi, Carlo Canna, Matteo Minozzi, Tommaso Allan, Callum Braley; Andrea Lovotti, Luca Bigi (captain), Giosue Zilocchi, Alessandro Zanni, Niccolo Cannone, Sebastian Negri, Jake Polledri, Abraham Steyn.
Replacements: Federico Zani, Danilo Fischetti, Marco Riccioni, Dean Budd, Federico Ruzza, Giovanni Licata, Guglielmo Palazzani, Giulio Bisegni.