Cheika has handed Sevens star Rodrigo Isgro his Pumas debut, starting on the wing.
Isgro was a part of the team that took bronze at the 2020 Olympics in Tokyo, joining fellow Olympian Lucio Cinti in the backline.
Prop Francisco Gómez Kodela also comes into the starting side after last week's defeat, with captain Julian Montoya remaining at hooker.
Cheika doesn't agree with the theory that he's under less pressure now coaching the Pumas than when he was while in charge of Australia.
"Pressure, there's two types," he said.
"There's the pressure that's applied from the outside and then there's the pressure that you apply on yourself, and I've always applied maximum pressure on myself because that's what I want to do.
"I want to test myself in the most difficult situations and see how I can help myself and the team come out on top. I want to be in that environment. I'm not worried about that environment.
"And that hardens you so that when you come to the external pressure, you've asked yourself all the questions that anyone wants to ask you anyway, if you're being genuine with yourself.
"It's more about ego. I want to win with Argentina as much as I've wanted to win with any other team I've coached."
Argentina: Emiliano Boffelli; Rodrigo Isgro, Lucio Cinti, Jeronimo De La Fuente; Mateo Carreras, Santiago Carreras, Gonzalo Bertranou; Juan Martin Gonzalez, Santiago Grondona, Pablo Matera; Tomas Lavanini, Matias Alemanno; Francisco Gomez Kodela, Julian Montoya (capt), Thomas Gallo
Replacements: Agustin Creevy, Hahuel Tetaz Chaparro, Eduardo Bello, Lucas Paulos, Rodrigo Bruni, Lautaro Bazan Velez, Nicolas Sanchez, Matias Moroni
